Ghana coach Kwesi Appiah says he will make a late decision on the availability of Asamoah Gyan and Kevin-Prince Boateng for the game against Zambia.
Both players have suffered fitness problems since the team's preparations got underway in Accra on Monday.
Appiah told a pre-match conference in Kumasi on Thursday that both players will be monitored before a firm decision will be made.
"He [Gyan] had some kind of muscle cramp and normally when such things happen, you need to rest and the doctors advised that he needed to," Appiah said.
"We will see whether he takes part or not but looking at the performance, he should be okay."
Boateng, who could play his second game for Ghana on home soil if selected also faces a late fitness test.
"The doctors advised that he [Kevin-Prince] was allowed to rest. If he returns to training today [Thursday] then, hopefully, he would be part of the team.
We are monitoring his fitness," the Ghana coach told media.
Ghana, sitting top of the Group D table and one point ahead of Zambia, need to avoid defeat to go through to the next round which will see the winners of the two-leg play-offs going on to Brazil.
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