Africa's second round of qualifying for the 2022 World Cup is set to kick off with some notable absentees - Mohamed Salah, among them - after the refusal of British clubs to release players for various matches.
Premier League clubs have led the way in refusing permission for players to head to countries on the British government's Covid red list, which would require 10 days of quarantine upon their return.
With Egypt one of 17 African countries on the red list, Liverpool superstar Salah will miss this week's home match against Angola in Cairo but could play in Gabon, which is not on the list, next week.
Quarantine conditions meant he could have been one of several internationals to miss multiple games, said Liverpool manager Jurgen Klopp.
"As clubs we cannot do that - not only because we play games in that time, but because without being positive (for coronavirus) they lose 10 days of training," he said.
"Without any chance of moving, you lose muscle. It's a real risk for the boys if they have to then play three, four or five days after 10 days in quarantine."
Since they are playing in countries not on the red list, Salah's club colleagues Sadio Mane and Naby Keita can represent Senegal and Guinea respectively in both this window's matches, which begin on Wednesday and end on Tuesday.
The Liverpool cases highlight the additional selection problems facing coaches as the 40 teams, split into ten groups of four, battle to reach March's play-offs.
Only the ten group winners will make the two-legged play-offs, whereupon Africa's five finalists for Qatar 2022 will be known.
This brings added intrigue to Group D, where Cameroon's 2017 African champions take on Ivory Coast's 2015 winners in a battle of sides who have ten World Cup appearances between them.
This is one of four groups featuring more than one team with World Cup experience, along with Group F (Egypt, Angola), Group G (South Africa, Ghana) and Group H (Senegal, Togo).
With the strengths of teams likely to be influenced by Covid complications for some time, the campaign has the capacity to throw up some surprise results.
An example of the challenges can be seen by the problems facing Nigeria coach Gernot Rohr, who named an expanded 30-man squad to cater for players not allowed to leave the United Kingdom.
While the Super Eagles will be at full strength at home to Liberia later this week, they are set to miss eight players based in the United Kingdom - with Leicester duo Kelechi Iheanacho and Wilfred Ndidi - for the trip that follows to Cape Verde, which is on the red list.
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